KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
25.45
Human Site:
T242
Identified Species:
40
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T242
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T242
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T242
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
Dog
Lupus familis
XP_543464
544
61233
T243
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T246
K
M
A
F
E
R
K
T
C
Q
K
V
A
I
K
Rat
Rattus norvegicus
NP_446129
545
60912
T245
K
M
A
F
E
R
K
T
C
K
K
V
A
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
S235
I
I
S
K
R
K
F
S
F
C
S
V
R
E
A
Chicken
Gallus gallus
NP_001073576
522
58779
R239
K
F
M
A
S
G
G
R
E
A
N
P
A
F
N
Frog
Xenopus laevis
NP_001082016
517
58243
S233
R
K
F
K
M
N
T
S
S
N
E
H
P
I
S
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
F160
I
I
Q
L
M
E
V
F
E
T
A
E
R
V
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
P215
N
M
L
S
G
A
R
P
S
T
N
F
S
D
P
Honey Bee
Apis mellifera
XP_624334
480
54300
E218
D
P
E
K
I
M
N
E
V
K
I
L
K
A
L
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
K215
R
C
S
R
A
I
A
K
T
R
D
I
R
N
E
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
K218
T
M
V
R
N
M
E
K
T
V
M
E
E
V
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
H232
Q
V
A
V
K
I
F
H
A
Q
Q
N
D
D
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
6.6
13.3
6.6
0
N.A.
0
6.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
13.3
26.6
13.3
N.A.
20
13.3
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
47
7
7
7
7
0
7
7
7
0
47
7
7
% A
% Cys:
0
7
0
0
0
0
0
0
40
7
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
0
0
7
0
7
14
0
% D
% Glu:
0
0
7
0
40
7
7
7
14
0
7
14
7
7
7
% E
% Phe:
0
7
7
40
0
0
14
7
7
0
0
7
0
7
0
% F
% Gly:
0
0
0
0
7
7
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
14
14
0
0
7
14
0
0
0
0
7
7
0
47
0
% I
% Lys:
47
7
0
20
7
7
40
14
0
40
40
0
7
0
40
% K
% Leu:
0
27
7
7
0
0
0
0
0
0
0
7
0
0
7
% L
% Met:
0
27
7
0
14
14
0
0
0
0
7
0
0
0
0
% M
% Asn:
7
0
0
0
7
7
7
0
0
7
14
7
0
7
7
% N
% Pro:
0
7
0
0
0
0
0
7
0
0
0
7
7
0
7
% P
% Gln:
7
0
7
0
0
0
0
0
0
14
7
0
0
0
7
% Q
% Arg:
14
0
0
14
7
40
7
7
0
7
0
0
20
0
7
% R
% Ser:
0
0
14
7
7
0
0
14
14
0
7
0
7
0
7
% S
% Thr:
7
0
0
0
0
0
7
40
14
14
0
0
0
0
0
% T
% Val:
0
7
7
7
0
0
7
0
7
7
0
47
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _